The defending NFC West champion San Francisco 49ers look to open 2-0 as they take on the Los Angeles Rams on Sunday. Both teams won on the road in Week 1 as San Francisco dominated Pittsburgh 30-7, while Los Angeles upset Seattle, 30-13. Last season, the 49ers swept both meetings, 24-9 in the Bay Area and 31-14 in Los Angeles.

Kickoff from SoFi Stadium in Los Angeles is scheduled for 4:05 p.m. ET. San Francisco is a 7.5-point favorite and the over/under for total points scored is 45 in the latest 49ers vs. Rams odds. Before making any Rams vs. 49ers picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2023 NFL season on an incredible 163-114 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-7 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Rams vs. 49ers and just locked in its picks and NFL Week 2 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Niners vs. Rams:

49ers vs. Rams spread: 49ers -7.549ers vs. Rams over/under: 45 points49ers vs. Rams money line: 49ers -339, Rams +27049ers vs. Rams picks: See picks at SportsLine49ers vs. Rams live stream: fubo (try for free)

Why the 49ers can cover

San Francisco running back Christian McCaffrey was dominant in the first game of the 2023 regular season, rushing for 152 yards on 22 carries including a 65 yard touchdown run in the third quarter. In his return from…