The New York Giants look to score their first points of the 2023 season as they head to the desert to take on the Arizona Cardinals in a battle of 0-1 teams on Sunday. The Giants were shut out at home on Sunday night by the Cowboys, 40-0, while the Cardinals fell to the Washington Commanders, 20-16. The teams most recently played in 2020, a 26-7 Cardinals road win. 

Kickoff from State Farm Stadium in Glendale, AZ is scheduled for 4:05 p.m. ET. The Giants are listed as a 4-point favorite and the over/under for total points scored is 39.5 in the latest Giants vs. Cardinals odds. Before making any Cardinals vs. Giants picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2023 NFL season on an incredible 163-114 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-7 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Giants vs. Cardinals and just locked in its picks and NFL Week 2 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Giants vs. Cardinals:

Giants vs. Cardinals spread: Giants -4Giants vs. Cardinals over/under: 39.5 pointsGiants vs. Cardinals money line: Giants -206, Cardinals +171Giants vs. Cardinals picks: See picks at SportsLine

Why the Giants can cover

To say it was a miserable season opener for the Giants would be an understatement. New York managed only 171 total yards against the Cowboys and committed…