49ers vs. Cardinals prediction, odds, line, spread, time: 2024 NFL picks, Week 5 best bets from advanced model

The defending NFC champion San Francisco 49ers look to win at home for the second consecutive week as they host NFC West division rival, the Arizona Cardinals on Sunday afternoon. The Niners (2-2) beat the Patriots last week, 30-13, while the Cardinals (1-3) fell at home to the Commanders, 42-14. San Francisco has won four straight meetings between the two teams, having scored 38, 38, 35 and 45 points in their matchups against Arizona since the 2022 season.

Kickoff from Levi’s Stadium is set for 4:05 p.m. ET. San Francisco is a 7.5-point favorite in the latest 49ers vs. Cardinals odds, per SportsLine consensus, while the over/under for total points is 50. Before making any Cardinals vs. 49ers picks, you need to see the NFL predictions and betting advice from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2024 NFL season on an incredible 188-131 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 42-23 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cardinals vs. 49ers and just locked in its picks and NFL Week 5 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for spread, money line and over/under:

49ers vs. Cardinals spread: 49ers -749ers vs. Cardinals over/under: 50 points49ers vs. Cardinals money line: 49ers -357, Cardinals +28149ers vs. Cardinals picks: See picks at SportsLine49ers vs. Cardinals streaming: FuboTV (Try for free)

Why the Cardinals can cover

If Arizona is to play San…

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Author : CBS Sports Staff

Publish date : 2024-10-05 10:40:14

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